کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944547 1053221 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physical–chemical principles underlying RTK activation, and their implications for human disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Physical–chemical principles underlying RTK activation, and their implications for human disease
چکیده انگلیسی

RTKs, the second largest family of membrane receptors, exert control over cell proliferation, differentiation and migration. In recent years, our understanding of RTK structure and activation in health and disease has skyrocketed. Here we describe experimental approaches used to interrogate RTKs, and we review the quantitative biophysical frameworks and structural considerations that shape our understanding of RTK function. We discuss current knowledge about RTK interactions, focusing on the role of different domains in RTK homodimerization, and on the importance and challenges in RTK heterodimerization studies. We also review our understanding of pathogenic RTK mutations, and the underlying physical–chemical causes for the pathologies. This article is part of a Special Issue entitled: Protein Folding in Membranes.


► Physical–chemical models provide an adequate description of RTK activation.
► Quantitative experimental methods shed new light on RTK function.
► Methods are available to characterize RTK homo and heterodimerization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1818, Issue 4, April 2012, Pages 995–1005
نویسندگان
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