کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1944745 1053239 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Na+-ATPase in spontaneous hypertensive rats: Possible AT1 receptor target in the development of hypertension
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Na+-ATPase in spontaneous hypertensive rats: Possible AT1 receptor target in the development of hypertension
چکیده انگلیسی

Clinical and experimental data show an increase in sodium reabsorption on the proximal tubule (PT) in essential hypertension. It is well known that there is a link between essential hypertension and renal angiotensin II (Ang II). The present study was designed to examine ouabain-insensitive Na+-ATPase activity and its regulation by Ang II in spontaneously hypertensive rats (SHR). We observed that Na+-ATPase activity was enhanced in 14-week-old but not in 6-week-old SHR. The addition of Ang II from 10− 12 to 10− 6 mol/L decreased the enzyme activity in SHR to a level similar to that obtained in WKY. The Ang II inhibitory effect was completely reversed by a specific antagonist of AT2 receptor, PD123319 (10− 8 mol/L) indicating that a system leading to activation of the enzyme in SHR is inhibited by AT2-mediated Ang II. Treatment of SHR with losartan for 10 weeks (weeks 4–14) prevents the increase in Na+-ATPase activity observed in 14-week-old SHR. These results indicate a correlation between AT1 receptor activation in SHR and increased ouabain-insensitive Na+-ATPase activity. Our results open new possibilities towards our understanding of the pathophysiological mechanisms involved in the increased sodium reabsorption in PT found in essential hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1798, Issue 3, March 2010, Pages 360–366
نویسندگان
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