کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1945056 | 1053250 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ceramide-enriched membrane domains—Structure and function Ceramide-enriched membrane domains—Structure and function](/preview/png/1945056.png)
Membrane lipids seem to be organized and not randomly distributed in the cell membrane. In particular, sphingolipids seem to interact with cholesterol in the outer leaflet of the cell membrane resulting in the formation of distinct membrane domains, i.e. rafts. The generation of ceramide within rafts alters their biophysical properties and results in the formation of large ceramide-enriched membrane platforms. These platforms serve to cluster receptor molecules and to organize intracellular signalling molecules to facilitate signal transduction via a receptor upon stimulation. Thus, ceramide-enriched membrane domains amplify not only receptor-, but also stress-mediated signalling events. Although many receptors cluster, the molecular mechanisms mediating this important and general event in signal transduction need to be identified.
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1788, Issue 1, January 2009, Pages 178–183