کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1945084 1053251 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ca2+ transport and heat production in vesicles derived from the sarcoplasmic reticulum terminal cisternae: Regulation by K+
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ca2+ transport and heat production in vesicles derived from the sarcoplasmic reticulum terminal cisternae: Regulation by K+
چکیده انگلیسی

In this work, we compared the effect of K+ on vesicles derived from the longitudinal (LSR) and terminal cisternae (HSR) of rabbit white muscle. In HSR, K+ was found to inhibit both the Ca2+ accumulation and the heat released during ATP hydrolysis by the Ca2+-ATPase (SERCA1). This was not observed in LSR. Valinomycin abolished the HSR Ca2+-uptake inhibition promoted by physiological K+ concentrations, but it did not modify the thermogenic activity of the Ca2+ pump. The results with HSR are difficult to interpret, assuming that a single K+ is binding to either the ryanodine channel or to the Ca2+-ATPase. It is suggested that an increase of K+ in the assay medium alters the interactions among the various proteins found in HSR, thus modifying the properties of both the ryanodine channel and SERCA1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1788, Issue 7, July 2009, Pages 1517–1522
نویسندگان
, , ,