کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1946061 1053285 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
cAMP regulates vasopressin-induced AQP2 expression via protein kinase A-independent pathway
چکیده انگلیسی

The regulation of AVP-induced AQP2 expression was investigated in the present study. AVP administration induced AQP2 expression in a dose-dependent manner in association with an increase in intracellular cAMP concentration. PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression. However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression. These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1758, Issue 8, August 2006, Pages 1100–1105
نویسندگان
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