کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1946578 1054256 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple modes of chromatin remodeling by Forkhead box proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Multiple modes of chromatin remodeling by Forkhead box proteins
چکیده انگلیسی

Forkhead box (FOX) proteins represent a large family of transcriptional regulators unified by their DNA binding domain (DBD) known as a ‘forkhead’ or ‘winged helix’ domain. Over 40 FOX genes have been identified in the mammalian genome. FOX proteins share significant sequence similarities in the DBD which allow them to bind to a consensus DNA response element. However, their modes of action are quite diverse as they regulate gene expression by acting as pioneer factors, transcription factors, or both. This review focuses on the mechanisms of chromatin remodeling with an emphasis on three sub-classes—FOXA, FOXO, and FOXP members. FOXA proteins serve as pioneer factors to open up local chromatin structure and thereby increase accessibility of chromatin to factors regulating transcription. FOXP proteins, in contrast, function as classic transcription factors to recruit a variety of chromatin modifying enzymes to regulate gene expression. FOXO proteins represent a hybrid subclass having dual roles as pioneering factors and transcription factors. A subset of FOX proteins interacts with condensed mitotic chromatin and may function as ‘bookmarking’ agents to maintain transcriptional competence at specific genomic sites. The overall diversity in chromatin remodeling function by FOX proteins is related to unique structural motifs present within the DBD flanking regions that govern selective interactions with core histones and/or chromatin coregulatory proteins. This article is part of a Special Issue entitled: Chromatin in time and space.


► Different chromatin remodeling mechanisms by Forkhead box proteins are reviewed.
► They carry out diverse remodeling as pioneer factors, transcription factors or both.
► They possess a conserved Forkhead box domain giving specificity in DNA recognition.
► N- and C-termini regions flanking DBD provide functional diversity.
► Unique flanking motifs specify interactions with histones and chromatin coregulators.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1819, Issue 7, July 2012, Pages 707–715
نویسندگان
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