کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1946600 | 1537283 | 2011 | 13 صفحه PDF | دانلود رایگان |
RNA silencing refers to processes that depend on small (s)RNAs to regulate the expression of eukaryotic genomes. In plants, these processes play critical roles in development, in responses to a wide array of stresses, in maintaining genome integrity and in defense against viral and bacterial pathogens. We provide here an updated view on the array of endogenous sRNA pathways, including microRNAs (miRNAs), discovered in the model plant Arabidopsis, which are also the basis for antiviral silencing. We emphasize the current knowledge as well as the recent advances made on understanding the defense and counter-defense strategies evolved in the arms race between plants and DNA viruses on both the nuclear and the cytoplasmic front. This article is part of a Special Issue entitled: MicroRNA's in viral gene regulation.
Research highlights
► We describe the different types of RNA silencing pathways that have been discovered in plants.
► We describe how the RNA silencing machinery is involved in defense mechanism against DNA viruses.
► We highlight the different RNA silencing suppressor proteins of DNA viruses that are involved in counteracting the RNA silencing machinery.
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1809, Issues 11–12, November–December 2011, Pages 588–600