کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1947020 1054288 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter
چکیده انگلیسی

The α-SG promoter is composed of a plethora of cis-regulatory elements, whose individual contribution to α-SG gene expression modulation remains unknown. We have identified a negative regulatory element in the α-SG distal promoter including two conserved E-boxes (E1 and E2), which interact with MyoD. We found that E1 and E2 negatively modulate the transactivation potential of MyoD on the α-SG core promoter. Moreover, such negative effect is mainly mediated by E2, which is surrounded by conserved nucleotides conferring MyoD binding capacity. Our results suggest that modulation of MyoD activity by E1, and particularly E2, contributes to the negative regulation of α-SG gene expression during myogenic differentiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1779, Issue 1, January 2008, Pages 74–80
نویسندگان
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