Spectrofluorimetric analysis of the interaction of amyloid peptides with neuronal nitric oxide synthase: Implications in Alzheimer's disease

► Interaction of Aβ17-28, Aβ25-25, Aβ32-35 with nitric oxide synthase by fluorescence. ► FRET showed 2 Trp residues moved 0.77 and 0.57 nm as Aβ17-28, Aβ25-25 became bound. ► Hydrophobic amyloid peptides bind at a site remote to the active region.