Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1

► We cloned zebrafish CL-P1 gene. ► Zebrafish CL-P1 is 51% identical to human CL-P1 in its amino acid sequence. ► CL-P1 knockdown induced vascular and developmental defects in the zebrafish. ► The scavenger receptor and collectin was involved in embryonic development in fish.