Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes

► AGEs elicit oxidative stress generation and subsequently cause inflammatory and thrombogenic reactions via interaction with a receptor for AGEs (RAGE). ► Mitochondrial superoxide generation plays an important role in the formation and accumulation of AGEs under diabetic conditions. ► A pathophysiological crosstalk between AGE-RAGE axis and renin-angiotensin system could contribute to vascular complications in diabetes. ► Inhibition of AGEs-RAGE-oxidative stress system is a therapeutic target for preventing vascular complications in diabetes.