Nox enzymes in allergic airway inflammation

► NADPH oxidases (NOX) are a primary source of ROS production during chronic inflammation. ► NOX enzymes are critical in host defense, as well as tissue (re)generation and remodeling. ► The contributions of NOX enzymes to asthma pathology are multifactorial. ► Selective targeting of specific NOX enzymes may be useful in treatment of asthma.