The Mössbauer and magnetic properties of ferritin cores

Background: Mössbauer and magnetization measurements, singly or in combination, extract detailed information on the microscopic or internal magnetism of iron-based materials and their macroscopic or bulk magnetization. The combination of the two techniques affords a powerful investigatory probe into spin relaxation processes of nanosize magnetic systems. The ferritin core constitutes a paradigm of such nano-magnetic system where Mössbauer and magnetization studies have been broadly combined in order to elucidate its composition, the initial steps of iron nucleation and biomineralization, particle growth and core-size distribution. In vivo produced and in vitro reconstituted wild-type and variant ferritins have been extensively studied in order to elucidate structure/function correlations and ferritin's role in iron overloading or neurodegenerative disorders.Scope of Review: Studies on the initial stages of iron biomineralization, biomimetic synthetic analogues and ferrous ion retention within the ferritin core are presented. The dynamical magnetic properties of ferritin by Mössbauer and magnetization measurements are critically reviewed. The focus is on experiments that reveal the internal magnetic structure of the ferritin core. Novel magnetic measurements on individual ferritin molecules via AFM and nanoSQUID investigations are also mentioned. Major Conclusions: A complex two-phase spin system is revealed due to finite-size effects and non-compensated spins at the surface of the anti-ferromagnetic ferritin core. Below the blocking temperature surface spins participate in relaxation processes much faster than those associated with collective magnetic excitations of interior spins. General Significance: The studies reviewed contribute uniquely to the elucidation of the spin-structure and spin-dynamics of anti-ferromagnetic nanolattices and their possible applications to nano/bio-technology.