کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1948463 1537492 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated cholesterol reduces acetylsalicylic acid-mediated platelet acetylation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Elevated cholesterol reduces acetylsalicylic acid-mediated platelet acetylation
چکیده انگلیسی

We describe the role of plasma and platelet cholesterol content in the ability of acetylsalicylic acid (ASA) to acetylate platelet proteins and inhibit platelet function. Platelet susceptibility to ASA was monitored in subjects differing in plasma total cholesterol and in suspensions of cholesterol-enriched or cholesterol-depleted platelets. Platelets from subjects with higher plasma cholesterol (> 6 mmol/l) showed reduced platelet sensitivity to ASA (inhibition of platelet aggregation and thromboxane generation by 60% and 68% in ‘lower-‘ vs. 32% and 56% in ‘higher-cholesterol’ donors; n = 13 in each group; p = 0.056 and p < 0.04, respectively). [Acetyl-1-14C] incorporation to platelet proteins in subjects with higher plasma cholesterol was significantly reduced (11.0 vs. 14.6 nmol/g protein, p < 0.0001) and correlated significantly with blood total cholesterolemia (RK = − 0.430, p < 0.003) and LDL-cholesterol (RK = − 0.349, p < 0.012), but not with platelet cholesterol content. In conclusion, elevated plasma cholesterol is an important determinant of ASA-induced acetylation of platelets and platelet diminished sensitivity to ASA. The molecular basis of such an association remains obscure, notwithstanding it may constitute a link between sub-optimal platelet response to aspirin and lipid metabolic disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1770, Issue 12, December 2007, Pages 1651–1659
نویسندگان
, , , , , , , , , , ,