کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1948495 1054697 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
چکیده انگلیسی

The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important clinical drug target. This review updates information on the variety of the CYP51 family members, including their physiological roles, natural substrates and substrate preferences, and catalytic properties in vitro. We present experimental support for the notion that specific conserved regions in the P450 sequences represent a CYP51 signature. Two possible roles of CYP51 in P450 evolution are discussed and the major approaches for CYP51 inhibition are summarized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - General Subjects - Volume 1770, Issue 3, March 2007, Pages 467–477
نویسندگان
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