کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949110 1537722 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tissue-specific actions of FXR in metabolism and cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Tissue-specific actions of FXR in metabolism and cancer
چکیده انگلیسی


• FXR is critically involved in metabolic homeostasis in the gut-liver axis.
• Novel FXR modulators are in clinical trials for metabolic diseases.
• Tissue-specific FXR transgenic mice increased our understanding in FXR physiology.
• FXR is beneficial in metabolic and inflammatory diseases, and supposedly in cancer.

The nuclear Farnesoid X Receptor (FXR) is a transcription factor critically involved in metabolic homeostasis in the gut-liver axis. FXR activity is mediated by hormonal and dietary signals and driven by bile acids (BAs), which are the natural FXR ligands. Given the great physiological importance in BA homeostasis, as well as in the regulation of glucose and lipid metabolism, FXR plays a pivotal role in the pathogenesis of a wide range of disease of the liver, biliary tract and intestine, including hepatic and colorectal cancer. In the last years several studies have shown the relative FXR tissue-specific importance, highlighting synergism and additive effects in the liver and intestine. Gain- and loss-of-FXR-function mouse models have been generated in order to identify the biological processes and the molecular FXR targets. Taking advantage of the knowledge on the structure-activity relationship of BAs for FXR, semi-synthetic and synthetic molecules have been generated to obtain more selective and powerful FXR activators than BAs. This article is part of a Special Issue entitled: Linking transcription to physiology in lipodomics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1851, Issue 1, January 2015, Pages 30–39
نویسندگان
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