کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949166 1537727 2014 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemical modulation of glycerolipid signaling and metabolic pathways
ترجمه فارسی عنوان
مدولاسیون شیمیایی سیگنالینگ گالیسریلیپید و مسیرهای متابولیکی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Glycerolipid-signaling pathways play an important role in human physiology and disease.
• Glycerolipid-metabolizing enzymes are attractive targets for therapeutic intervention.
• Chemical modulators interrupting glycerolipid signaling are essential tools in research.

Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields—ranging from neuroscience and cancer to diabetes and obesity—have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. This article is part of a Special Issue entitled Tools to study lipid functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 8, August 2014, Pages 1060–1084
نویسندگان
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