کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949331 1537746 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lysophospholipid receptor activation of RhoA and lipid signaling pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Lysophospholipid receptor activation of RhoA and lipid signaling pathways
چکیده انگلیسی

The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) signal through G-protein coupled receptors (GPCRs) which couple to multiple G-proteins and their effectors. These GPCRs are quite efficacious in coupling to the Gα12/13 family of G-proteins, which stimulate guanine nucleotide exchange factors (GEFs) for RhoA. Activated RhoA subsequently regulates downstream enzymes that transduce signals which affect the actin cytoskeleton, gene expression, cell proliferation and cell survival. Remarkably many of the enzymes regulated downstream of RhoA either use phospholipids as substrates (e.g. phospholipase D, phospholipase C-epsilon, PTEN, PI3 kinase) or are regulated by phospholipid products (e.g. protein kinase D, Akt). Thus lysophospholipids signal from outside of the cell and control phospholipid signaling processes within the cell that they target. Here we review evidence suggesting an integrative role for RhoA in responding to lysophospholipids upregulated in the pathophysiological environment, and in transducing this signal to cellular responses through effects on phospholipid regulatory or phospholipid regulated enzymes. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.


► Lysophospholipid receptors couple to G12/13 and activation of RhoA.
► RhoA stimulates phospholipases and lipid regulated enzymes.
► Phospholipase D and C (epsilon) and protein kinase D mediate RhoA signaling.
► S1P and LPA elicit pathophysiological responses through these RhoA effectors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1831, Issue 1, January 2013, Pages 213–222
نویسندگان
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