Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPK

► Araquidonic acid (AA) is a mitogen for brown adipocytes inducing DNA synthesis. ► NE increases the mitogenic action of AA, growth factors and NE. ► AA increases the action of other mitogens of brown adipocytes. ► The mitogenic actions of AA and other mitogens are mediated through PKC and MAPK. ► PKC delta seems involved in AA-induced proliferation.