Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice

► ABCG1 expression is markedly elevated by obesity and caloric restriction (CR). ► Adipose tissue macrophage (MO) phenotypes are altered by acute caloric restriction. ► CR leads to cholesterol loaded peritoneal MO and elevations in ABCG1, ABCA1 and apoE.