A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models

► We investigate genetic factors affecting HDL in a CASTxB6 F2 mouse cross. ► Network analysis identifies gene co-expression modules associated with HDL. ► Studies across independent data sets confirm robustness of identified modules. ► Using meta-analysis techniques we identify genes consistently associated with HDL. ► Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting HDL levels.