Connecting vesicular transport with lipid synthesis: FAPP2

► FAPP2 contains a PtdIns4P (and ARF1) binding PH domain and a GLTP (Glycolipid Transfer Protein) domain. ► The FAPP2-PH domain targets the protein to the trans-Golgi network and has membrane bending activity. ► Via the GLTP domain FAPP2 transfers glucosylceramide and fosters complex glycolipid synthesis at the Golgi complex. ► FAPP2 controls TGN-to-plasma membrane vesicular trafficking by assisting the formation of post-Golgi carriers. ► The lipid-transfer activity of FAPP2 is required for its role in membrane trafficking.