Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network

► PKD phosphorylates PI4KIIIβ, CERT and OSBP, all of which are involved in lipid metabolism or trafficking. ► This molecular network coordinates non-vesicular and vesicular trafficking ensuring proper Golgi function. ► CERT-mediated non-vesicular ceramide transfer occurs at ER-Golgi membrane contact sites. ► Deregulated CERT is involved in human pathologies and its function is exploited by human pathogens.