Overexpression of gankyrin induces liver steatosis in zebrafish (Danio rerio)

► Overexpression of gankyrin induces hepatic steatosis in zebrafish. ► Transgenic gankyrin zebrafish (GK) have altered expression of 22 lipiogenic genes. ► miR-16, miR-27b, miR-122, and miR-126 are deregulated in the livers of GK fish. ► Overexpression of gankyrin induces hepatic lipoapoptosis and liver degeneration. ► Overexpression of gankyrin increases de novo free fatty acid synthesis pathways.