کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950190 1537816 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calcium-independent phospholipase A2 and apoptosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Calcium-independent phospholipase A2 and apoptosis
چکیده انگلیسی

Apoptosis or programmed cell death is associated with changes in glycerophospholipid metabolism. Cells undergoing apoptosis generally release free fatty acids including arachidonic acid, which parallels the reduction in cell viability. The involvement of cytosolic group IVA phospholipase A2α (cPLA2α) in apoptosis has been the subject of numerous studies but a clear picture of the role(s) played by this enzyme is yet to emerge. More recently, the importance of lipid products generated by the action of a second phospholipase A2, the group VIA calcium-independent phospholipase A2 (iPLA2-VIA) in apoptosis has begun to be unveiled. Current evidence suggests that iPLA2-VIA-derived lysophosphatidylcholine may play a prominent role in mediating the chemoattractant and recognition/engulfment signals that accompany the process of apoptotic cell death, and gives possibility to the efficient clearance of dying cells by circulating phagocytes. Other lines of evidence suggest that perturbations in the control of free arachidonic acid levels within the cells, a process that may implicate iPLA2-VIA as well, may provide important cellular signals for the onset of apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1761, Issue 11, November 2006, Pages 1344–1350
نویسندگان
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