Cohesin: A guardian of genome integrity

► Discussed the latest research on life cycle of cohesin with special emphasis on S. cerevisiae. ► Comparison between budding yeast cohesin/cohesion mechanism with that of the other model eukaryotes. ► Interactome table of cohesin has been provided to understand the complexity of its regulatory network. ► Tabular compilation to highlight the role of posttranslational modifications in cohesin biology.