کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1950708 1055692 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein degradation and iron homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Protein degradation and iron homeostasis
چکیده انگلیسی

Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia Inducible Factor (HIF), and ferroportin. Notably, the stability of each of these proteins is regulated in response to iron. Recent discoveries have greatly advanced our understanding of the molecular mechanisms governing iron-sensing and protein degradation within these pathways. It has become clear that iron's privileged roles in both enzyme catalysis and protein structure contribute to its regulation of protein stability. Moreover, these multiple pathways intersect with one another in larger regulatory networks to maintain iron homeostasis. This article is part of a Special Issue entitled: Cell Biology of Metals.


► Regulation of iron homeostasis requires the capacity to sense iron levels.
► Iron levels affect changes in expression of proteins mediating iron metabolism.
► The stability of many proteins is governed through regulated protein degradation.
► Mechanisms linking iron sensing and protein degradation are becoming clearer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1823, Issue 9, September 2012, Pages 1484–1490
نویسندگان
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