کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1951218 1055749 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear targeting of FBPase in HL-1 cells is controlled by beta-1 adrenergic receptor-activated Gs protein signaling cascade
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Nuclear targeting of FBPase in HL-1 cells is controlled by beta-1 adrenergic receptor-activated Gs protein signaling cascade
چکیده انگلیسی

Muscle fructose 1,6-bisphosphatase (FBPase), a well-known regulatory enzyme of glyconeogenic pathway has recently been found inside nuclei of several cell types (cardiomyocytes, smooth muscle cells, myogenic progenitor cells). This surprising finding raised a question concerning the role of FBPase in this compartment of the cell, and of the extracellular signals regulating nuclear transport of the enzyme. In the present paper we show that, in HL-1 cardiomyocyte cell line, the activity of adenylyl cyclase and cAMP-dependent protein kinase A is essential to nuclear import of FBPase. The import is also stimulated by isoproterenol (a nonselective β-adrenergic receptors agonist) and inhibited by metoprolol (a selective β1 antagonist), strongly suggesting that nucleo-cytoplasmic shuttling of FBPase is under the control of β1-adrenergic receptor-dependent Gs protein signaling cascade.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1793, Issue 5, May 2009, Pages 871–877
نویسندگان
, , ,