کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1951508 1055771 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diverse functions of p120ctn in tumors
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Diverse functions of p120ctn in tumors
چکیده انگلیسی

p120ctn is a member of the Armadillo protein family. It stabilizes the cadherin–catenin adhesion complex at the plasma membrane, but also has additional roles in the cytoplasm and nucleus. Extensive alternative mRNA splicing and multiple phosphorylation sites generate additional complexity. Evidence is emerging that complete loss, downregulation or mislocalization of p120ctn correlates with progression of different types of human tumors. It remains to be determined whether a causal relationship exists between specific isoform expression, subcellular localization or selective phosphorylation of p120ctn on the one hand and tumor prognosis on the other.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1773, Issue 1, January 2007, Pages 78–88
نویسندگان
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