Cellular uptake of cobalamin: Transcobalamin and the TCblR/CD320 receptor

► This review provides a comprehensive account of the process of cellular uptake of vitamin B12 and the proteins involved. ► Provides information on transcobalamin, the plasma transporter of cobalamin. ► Provides information on the structure and function of the receptor for transcobalamin-bound cobalamin. ► Identifies gene defects of transcobalamin and its receptor.