کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1952297 1057201 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Up- and down-regulation of adiponectin expression and multimerization: Mechanisms and therapeutic implication
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Up- and down-regulation of adiponectin expression and multimerization: Mechanisms and therapeutic implication
چکیده انگلیسی

Adiponectin has been receiving a great deal of attention due to its potential therapeutic use for metabolic and cardiovascular disorders. Adiponectin expression levels and multimerization are down-regulated in obesity and up-regulated by insulin sensitizers such as thiazolidinediones (TZDs), metformin, sulfonylurea and resveratrol (RSV). The precise mechanisms underlying adiponectin up- and down-regulation remain largely unknown, but recent studies indicate that the cellular and plasma levels of adiponectin could be regulated at both transcriptional and post-transcriptional levels. At the post-translational level, TZDs and resveratrol promote adiponectin levels and multimerization via up-regulation of disulfide-bond-A oxidoreductase-like protein (DsbA-L). Adiponectin levels are also stimulated by FOXO1 and AMP-activated protein kinase (AMPK), and are suppressed by PKA or silencing mediator of retinoid and thyroid hormone receptors (SMRT). Since multimerization is important not only for adiponectin function but also for stability, increasing adiponectin multimerization has become a promising drug target for the treatment of metabolic diseases and other related disorders.


► PPARg activity is modulated by its phosphorylation and binding to other receptors.
► Adiponectin level could also be regulated by post-translational mechanisms in cells.
► Increasing adiponectin level could be an effective therapeutic approach.
► Increasing adiponectin multimerization could be an effective therapeutic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 94, Issue 10, October 2012, Pages 2126–2130
نویسندگان
, ,