کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1953539 | 1538438 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two domains are critical for the nuclear localization of soluble adenylyl cyclase
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کلمات کلیدی
SACTSACNLSscAMP - cAMPcyclic adenosine 3′,5′-monophosphate - آدنوزین cyclic 3 '، 5'-monophosphateadenylyl cyclase - آدنیلات سیکلاز، آدنیلیل سیکلازSoluble adenylyl cyclase - آدنیلیل سیکلاس قابل حل استImmunofluorescence - ایمونوفلورسانسnuclear localization signals - سیگنال های محلی سازی هسته ایNuclear localization - محلی سازی هسته ایnuclear envelope - پاکت هسته ای
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Two domains are critical for the nuclear localization of soluble adenylyl cyclase Two domains are critical for the nuclear localization of soluble adenylyl cyclase](/preview/png/1953539.png)
چکیده انگلیسی
Soluble adenylyl cyclase (sAC) is a newly identified source of cyclic adenosine 3â²,5â²-monophosphate (cAMP). Unlike the well-known transmembrane adenylyl cyclases (tmACs), sAC locates to the nucleus, mitochondria and microtubules. For most cAMP-signaling microdomains, there is always an AC nearby, for example tmAC. But it was until the discovery of sAC that there was not known cAMP resource in the nucleus. sAC associates with nuclear cAMP-signaling microdomains, which were once considered to depend on the diffusion of cAMP produced by tmAC. In this report, we focus on the truncated soluble adenylyl cyclase (tsAC), the most common existence form of sAC in tissues. Two domains (145-200 aa and 257-318 aa) related with sAC nuclear localization were present here. The findings provide evidence that these two domains are critical for the nuclear localization of sAC and they collocated with the catalytic domains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 88, Issues 3â4, MarchâApril 2006, Pages 319-328
Journal: Biochimie - Volume 88, Issues 3â4, MarchâApril 2006, Pages 319-328
نویسندگان
Qiping Feng, Yongwei Zhang, Yunfeng Li, Zhuo Liu, Jin Zuo, Fude Fang,