کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1956558 1057863 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extending a Spectrin Repeat Unit. I: Linear Force-Extension Response
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Extending a Spectrin Repeat Unit. I: Linear Force-Extension Response
چکیده انگلیسی

Nonequilibrium molecular dynamics simulations were used to calculate the elastic properties of a spectrin repeat unit. A contiguous α-helical linker was constructed by employing periodic boundary conditions, allowing a novel scheme for evaluating the thermodynamic force as a function of extension. By measuring the force-extension response under small extensions, spectrin was observed to behave primarily as an elastic material with a spring constant of 1700 ± 100 pN/nm. The implications of this spring constant, in terms of the properties of the spectrin tetramer, are also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 90, Issue 1, 1 January 2006, Pages 92–100
نویسندگان
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