کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1956662 1057865 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Theoretical Study of Sequence-Dependent Nanopore Unzipping of DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Theoretical Study of Sequence-Dependent Nanopore Unzipping of DNA
چکیده انگلیسی

We theoretically investigate the unzipping of DNA electrically driven through a nanometer-size pore. Taking the DNA base sequence explicitly into account, the unpairing and translocation process is described by a biased random walk in a one-dimensional energy landscape determined by the sequential basepair opening. Distributions of translocation times are numerically calculated as a function of applied voltage and temperature. We show that varying these two parameters changes the dynamics from a predominantly diffusive behavior to a dynamics governed by jumps over local energy barriers. The work suggests experimentally studying sequence effects, by comparing the average value and standard deviation of the statistical distribution of translocation times.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 94, Issue 7, April 2008, Pages 2716–2724
نویسندگان
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