کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1957237 1057878 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Folding Thermodynamics of Peptides
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Folding Thermodynamics of Peptides
چکیده انگلیسی

A simplified interaction potential for protein folding studies at the atomic level is discussed and tested on a set of peptides with ∼20 residues each. The test set contains both α-helical (Trp cage, Fs) and β-sheet (GB1p, GB1m2, GB1m3, Betanova, LLM) peptides. The model, which is entirely sequence-based, is able to fold these different peptides for one and the same choice of model parameters. Furthermore, the melting behavior of the peptides is in good quantitative agreement with experimental data. Apparent folded populations obtained using different observables are compared, and are found to be very different for some of the peptides (e.g., Betanova). In other cases (in particular, GB1m2 and GB1m3), the different estimates agree reasonably well, indicating a more two-state-like melting behavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 88, Issue 3, March 2005, Pages 1560–1569
نویسندگان
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