کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1959184 1057929 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Two-Pathway Model for the Catch-Slip Transition in Biological Adhesion
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The Two-Pathway Model for the Catch-Slip Transition in Biological Adhesion
چکیده انگلیسی

Some recently studied biological noncovalent bonds have shown increased lifetime when stretched by mechanical force. In each case these counterintuitive “catch-bonds” have transitioned into ordinary “slip-bonds” that become increasingly shorter lived as the tensile force on the bond is further increased. We describe analytically how these results are supported by a physical model whereby the ligand escapes the receptor binding site via two alternative routes, a catch-pathway that is opposed by the applied force and a slip-pathway that is promoted by force. The model predicts under what conditions and at what critical force the catch-to-slip transition would be observed, as well as the degree to which the bond lifetime is enhanced at the critical force. The model is applied to four experimentally studied systems taken from the literature, involving the binding of P- and L-selectins to sialyl LewisX oligosaccharide-containing ligands. Good quantitative fit to the experimental data is obtained, both for experiments with a constant force and for experiments where the force increases linearly with time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 89, Issue 3, September 2005, Pages 1446–1454
نویسندگان
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