کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1959495 1057940 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mathematical Modeling of Mitochondrial Adenine Nucleotide Translocase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mathematical Modeling of Mitochondrial Adenine Nucleotide Translocase
چکیده انگلیسی

We have developed a mathematical model of adenine nucleotide translocase (ANT) function on the basis of the structural and kinetic properties of the transporter. The model takes into account the effect of membrane potential, pH, and magnesium concentration on ATP and ADP exchange velocity. The parameters of the model have been estimated from experimental data. A satisfactory model should take into account the influence of the electric potential difference on both ternary complex formation and translocation processes. To describe the dependence of translocation constants on electric potential we have supposed that ANT molecules carry charged groups. These groups are shifted during the translocation. Using the model we have evaluated the translocator efficiency and predicted the behavior of ANT under physiological conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 90, Issue 2, 15 January 2006, Pages 423–432
نویسندگان
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