کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1959733 1057945 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Geometry of the Flux Cone of a Metabolic Network
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The Geometry of the Flux Cone of a Metabolic Network
چکیده انگلیسی

The analysis of metabolic networks has become a major topic in biotechnology in recent years. Applications range from the enhanced production of selected outputs to the prediction of genotype-phenotype relationships. The concepts used are based on the assumption of a pseudo steady-state of the network, so that for each metabolite inputs and outputs are balanced. The stoichiometric network analysis expands the steady state into a combination of nonredundant subnetworks with positive coefficients called extremal currents. Based on the unidirectional representation of the system these subnetworks form a convex cone in the flux-space. A modification of this approach allowing for reversible reactions led to the definition of elementary modes. Extreme pathways are obtained with the same method but splitting up internal reactions into forward and backward rates. In this study, we explore the relationship between these concepts. Due to the combinatorial explosion of the number of elementary modes in large networks, we promote a further set of metabolic routes, which we call the minimal generating set. It is the smallest subset of elementary modes required to describe all steady states of the system. For large-scale networks, the size of this set is of several magnitudes smaller than that of elementary modes and of extreme pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 89, Issue 6, December 2005, Pages 3837–3845
نویسندگان
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