کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1959759 1057945 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Molecular Dynamics Study of the Response of Lipid Bilayers and Monolayers to Trehalose
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
A Molecular Dynamics Study of the Response of Lipid Bilayers and Monolayers to Trehalose
چکیده انگلیسی

Surface tensions evaluated from molecular dynamics simulations of fully hydrated dipalmitoylphosphatidylcholine bilayers and monolayers at surface areas/lipid of 54, 64, and 80 Å2 are uniformly lowered 4–8 dyn/cm upon addition of trehalose in a 1:2 trehalose/lipid ratio. Constant surface tension simulations of bilayers yield the complementary result: an increase in surface area consistent with the surface pressure-surface area (π-A) isotherms. Hydrogen bonding by trehalose, replacement of waters in the headgroup region, and modulation of the dipole potential are all similar in bilayers and monolayers at the same surface area. These results strongly support the assumption that experimental measurements on the interactions of surface active components such as trehalose with monolayers can yield quantitative insight to their effects on bilayers. The simulations also indicate that the 20–30 dyn/cm difference in surface tension of the bilayer leaflet and monolayer arises from differences in the chain regions, not the headgroup/water interfaces.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 89, Issue 6, December 2005, Pages 4111–4121
نویسندگان
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