Function and evolution of ubiquitous bacterial signaling adapter phosphopeptide recognition domain FHA

► Phylogeny of FHA-containing bacteria was proposed for the first time and will help appreciation of this important signaling module. ► First summary of the function of FHA-containing protein in bacteria ► First comprehensive distribution survey of FHA-containing protein in bacteria ► Anti-FHA new chemical entity merits intensive investigation for inhibitors blocking signal-dependent protein-protein interactions.