Notch1-mediated signaling regulates proliferation of porcine satellite cells (PSCs)

► Knock-down of NOTCH1 decreases the proliferation of PSCs. ► Enhancement of NOTCH1 expression increases the proliferation of PSCs. ► Notch1 regulates the proliferation of PSCs through the activation of Hes5. ► Notch1 regulates the expression of cell cycle related genes and MRFs. ► Alterative expression of Notch1 in PSCs changes the expression of GSK3β-3.