The negative feedback regulation of TRPV4 Ca2 + ion channel function by its C-terminal cytoplasmic domain

The transient receptor potential vanilloid 4 (TRPV4) cation channel, a member of the TRP vanilloid subfamily, is expressed in a broad range of tissues where it participates in the generation of a Ca2 + signal and/or depolarization of the membrane potential. Regulation of the abundance of TRPV4 at the cell surface is critical in osmo- and mechanotransduction.In this review, we discussed that the potential effect of Ca2 + occurs via its action at an intracellular site in the C-terminus of the channel protein by the effect of the modulation on TRPV4 (such as 824 Ser residue phosphorylation), and its regulation for TRPV4 functions related with cell surface spread, wound healing or its polarity reorientation through its differential affinity with actin or tubulin.

► We discussed the regulation of TRPV4 Ca2 + channel.
► TRPV4 functions are regulated by the differential affinity with actin or tubulin.
► C-terminal cytoplasmic domain of TRPV4 is the negative feedback regulatory region.