An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells

► MKP5 has an essential role in ox-LDL-induced macrophage foam cell formation. ► MKP5 deficiency reduces the ox-LDL-induced activation of NF-κB. ► MKP5 up-regulates the activation of NF-κB and increases the foam cell formation.