کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1963773 | 1058504 | 2010 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathway Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathway](/preview/png/1963773.png)
The eukaryotic transcription factor NF-κB regulates a wide range of host genes that control the inflammatory and immune responses, programmed cell death, cell proliferation and differentiation. The activation of NF-κB is tightly controlled both in the cytoplasm and in the nucleus. While the upstream cytoplasmic regulatory events for the activation of NF-κB are well studied, much less is known about the nuclear regulation of NF-κB. Emerging evidence suggests that NF-κB undergoes a variety of posttranslational modifications, and that these modifications play a key role in determining the duration and strength of NF-κB nuclear activity as well as its transcriptional output. Here we summarize the recent advances in our understanding of the posttranslational modifications of NF-κB, the interplay between the various modifications, and the physiological relevance of these modifications.
Journal: Cellular Signalling - Volume 22, Issue 9, September 2010, Pages 1282–1290