کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1964587 1058561 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Involvement of glycogen synthase kinase-3β in hydrogen peroxide-induced suppression of Tcf/Lef-dependent transcriptional activity
چکیده انگلیسی

Hydrogen peroxide (H2O2) mediates induction of cytotoxicity in various cell types. GSK-3β has been found to participate in a number of signaling pathways, including cell proliferation and cell death. In the present study, we show that GSK-3β is rapidly dephosphorylated and activated in response to H2O2 treatment. H2O2 also dephosphorylates Akt/PKB in a dose- and time-dependent manner. Overexpression of Akt/PKB attenuates H2O2-induced dephosphorylation of GSK-3β. Ectopic expression of Dvl-1, a component of Wnt signaling, stimulates Akt/PKB and inhibits dephosphorylation of GSK-3β by H2O2. Furthermore, H2O2 causes the reduction of β-catenin level and LiCl-mediated activation of Tcf/Lef-dependent transcription activity. These findings suggest that GSK-3β is involved in H2O2-mediated inhibition of Tcf/Lef-dependent transcriptional activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 18, Issue 5, May 2006, Pages 601–607
نویسندگان
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