Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults

• Effects of bariatric weight loss surgery on serum TRACP 5a in obese adults
• Effects of bariatric weight loss surgery on glucose metabolism in obese adults
• Effects of bariatric weight loss surgery on inflammatory cytokines in obese adults

BackgroundWe determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults.MethodsSeverely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12 months postoperatively.ResultsData of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3 months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12 months in non-DM group, while improving significantly at 6 and 12 months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12 months in non-DM group and 12 months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3 months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6 months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12 months postoperatively without significant changes in CRP and IL-6.ConclusionWeight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.