High CA-125 and CA19-9 levels in spontaneous ruptured ovarian endometriomas

• CA-125 and CA19-9 levels were elevated in patients with spontaneous ruptured ovarian endometriomas.
• The AUC value of the combined biomarkers is much higher than CA-125 or CA19-9 alone.
• The spontaneous rupture of the ovarian endometrioma deserves more attention.

Background: To evaluate the clinical significance of serum CA-125 and CA19-9 in women with spontaneous ruptured ovarian endometriomas.Methods: From January 2006 to April 2015, a total of 1653 women were diagnosed with ovarian endometriomas, and 43 women were diagnosed with the spontaneous rupture of their ovarian endometrioma. In addition, 70 women diagnosed with unruptured ovarian endometriomas were chosen to serve as control subjects. Serum CA-125 and CA19-9 levels, together with the clinical materials, were collected.Results: Serum CA-125, CA19-9, and the combined biomarkers were shown to be obviously elevated in the spontaneous ruptured ovarian endometrioma group (p = 0.001, p = 0.001, p = 0.001, respectively). The AUC value for the combined biomarkers was 0.992 (95% CI, 0.981–1.000), with a high sensitivity and specificity of nearly 100% and 93.6%, respectively. Moreover, the maximum diameter of the mass was significantly (p = 0.001) increased in the ruptured group.Conclusions: Serum CA-125 and CA19-9 were significantly increased in patients with spontaneous ruptured ovarian endometriomas. Moreover, the combined biomarkers were better than either CA-125 or CA19-9 alone in the diagnosis of a spontaneous rupture of the ovarian endometrioma.