کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965630 1538708 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-peptin: Role as a novel biomarker in clinical practice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Co-peptin: Role as a novel biomarker in clinical practice
چکیده انگلیسی

BackgroundArginine vasopressin (AVP) is a key regulator of water balance, but its instability makes reliable measurement difficult and precludes its routine use. Co-peptin is the C-terminal part of the AVP precursor which plays an important role in the correct structural formation of the AVP precursor and its efficient proteolytic maturation. Because of its stoichiometric generation, co-peptin mirrors the release of AVP and measurement of more stable co-peptin may be an indicator of AVP levels.MethodA comprehensive literature search was conducted from the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data was assessed from books and journals that published relevant articles in this field.ResultRecent and ongoing research indicates the diagnostic and prognostic roles of co-peptin in various clinical settings especially in critically ill patients.ConclusionCo-peptin levels are altered in various physiological and pathological conditions indicating its possible role as a biomarker. However, further research using co-peptin in various clinical settings will prove its cost-effectiveness and clinical usefulness.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 412, Issues 1–2, 14 January 2011, Pages 22–28
نویسندگان
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