Changes in insulin sensitivity during GnRH agonist treatment in premenopausal women with leiomyoma

► We examined the influence of GnRH agonist on factors related to insulin resistance. ► In women who had a low HOMA-IR before GnRH agonist, HOMA-IR was increased. ► Levels of insulin, HOMA-IR and SHBG were decreased in women with high HOMA-IR.