کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1965694 1538680 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Relationships between serum osteocalcin, leptin and the effect of weight loss by pharmacological treatment in healthy, nonsmoking Korean obese adults
چکیده انگلیسی

BackgroundRecent studies have reported a relationship between osteocalcin (OC) levels and factors associated with energy metabolism and insulin resistance. As any detailed understanding of OC mechanisms still remains elusive, this study aimed at revealing a correlation between serum OC levels and obesity in healthy, nonsmoking, Korean obese adults who had undergone weight loss through pharmacological treatment.Methods119 healthy, nonsmoking, Korean obese adults were investigated at 3 months following weight loss through pharmacological treatment. Serum OC, leptin, HOMA score, ghrelin, visceral fat mass, total body fat, and BMI were measured.ResultsIncrease in serum OC was significantly associated with decreases in: BMI (and weight change %) (r = − 0.209, p = 0.023), visceral fat mass (r = − 0.189, p = 0.049), HOMA (r = − 0.203 p = 0.027), and leptin (r = − 0.253 p = 0.006), but not with changes in adiponectin (r = + 0.029, p = NS), and Ghrelin (r = + 0.019, p = NS). Decrease in leptin (β = − 0.280, p = 0.002) was significantly associated with an increase in serum OC, after pharmacological weight loss treatment was adjusted for age, sex, drug type, and BMI (or visceral fat mass).ConclusionsSerum OC was significantly increased at 3 months after pharmacological weight loss. We further found that leptin levels were associated with changes in serum OC. These findings suggest a relationship between bone and adipose tissue.


► Serum OC was significantly increased at 3 months after pharmacological weight loss
► We further found that leptin levels were associated with changes in serum OC.
► These findings suggest a relationship between bone and adipose tissue.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 418, 15 March 2013, Pages 17–21
نویسندگان
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